|
KMID : 0861020070220020163
|
|
Korea Journal of Herbology
2007 Volume.22 No. 2 p.163 ~ p.168
|
|
|
Effects of oral administration and herbal acupuncture with Sayeoksanhap-Pyeongweisan-Gamibang(SPG) on gene exdpression in rats damaged by CCl4
|
|
Kim Hyung-Woo
Jeong Byeong-Han
Kim Young-Kyoon
Back Jin-Woong
Cho Su-In
Kim Gye-Yeop
|
|
|
Abstract
|
|
|
Objectives : This study was designed to investigate effects of Sayeoksanhap-Pyeongweisan-Gambang (SPG) on gene expression in rats damaged by CCl4.
Methods : We investigated the effects of SPG on gene expression in terms of microarray methods in rat liver which were obtained from rats damaged by CCl4.
Results : Decreased gene expressions, which were induced by single injection of CCl4, were restored to those in normal rats by administration of SPG or herbal acupuncture. In acupuncture group, gene expressions were restored by 80% of those in control group. In oral administration group and combination group, gene expressions were restored above 90% of those in cuntrol group.
Conclusion : These results suggest that oral administraion of SPG was useful to protect liver against CCl4 by its restoration of gene expressions in liver resected from rat damaged by CCl4.
|
|
|
KEYWORD
|
|
|
Sayeoksan, Pyeongweisan, CCl4, Microarray, Gene expression
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|